Expanding the Chemical Space in Practice: Diversity-Oriented Synthesis

Author(s): Marine Peuchmaur, Yung-Sing Wong

Journal Name: Combinatorial Chemistry & High Throughput Screening
Accelerated Technologies for Biotechnology, Bioassays, Medicinal Chemistry and Natural Products Research

Volume 11 , Issue 8 , 2008

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Abstract:

Diversity-Oriented Synthesis (DOS) aims to broaden the frontier of accessible collections of complex and diverse small molecules. This review endeavours to dissect the DOS concept through three elements of diversity: building block, stereochemistry, and skeleton. Recent examples in the literature that emphasize the efficient combinations of these elements to generate diversity are reported.

Keywords: Diversity-Oriented Synthesis, small molecules, complexity, diversity, multicomponent reactions, stereodivergent reactions, skeletal divergent reactions, chemical space

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Article Details

VOLUME: 11
ISSUE: 8
Year: 2008
Page: [587 - 601]
Pages: 15
DOI: 10.2174/138620708785739916
Price: $65

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