Atherosclerosis and Inflammation: Insight from Carotid and Intracoronary Ultrasound Studies

Author(s): Syed Tahir, Anthony Nappi, Navin K. Kapur

Journal Name: Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry
(Formerly Current Medicinal Chemistry - Anti-Inflammatory & Anti-Allergy Agents)

Volume 7 , Issue 3 , 2008

Become EABM
Become Reviewer


Dating back to the early 1900s, clinical observations have pointed towards an intimate relationship between dyslipidemia, inflammation, and endothelial dysfunction in the pathogenesis of atherosclerosis. Despite a focus on aggressive lowering of low-density lipoprotein cholesterol (LDL-C) in patients at risk for developing cardiovascular disease, only moderate reductions in cardiovascular events have been achieved, suggesting other targets of therapy should be investigated. Over the past two decades pre-clinical and clinical data have demonstrated a direct correlation between inflammation and atheroma development. This review provides a detailed understanding of inflammation in atherogenesis with a particular emphasis on clinical studies correlating markers of inflammation with plaque progression using carotid intima-media thickness measurements and intravascular ultrasound.

Keywords: Atherosclerosis, inflammation, atherogenesis, soluble markers, intravascular ultrasound, carotid intima-media thickness.

Rights & PermissionsPrintExport Cite as

Article Details

Year: 2008
Page: [231 - 238]
Pages: 8
DOI: 10.2174/187152308785699227
Price: $65

Article Metrics

PDF: 4