Continuous Glucose Monitoring: Physiological and Technological Challenges

Author(s): Gerard Reach, Carine Choleau

Journal Name: Current Diabetes Reviews

Volume 4 , Issue 3 , 2008

Become EABM
Become Reviewer
Call for Editor


Over the past decade, several continuous glucose monitoring systems have been developed, representing remarkable technological achievements. Most of the systems monitor glucose invasively in the subcutaneous tissue. It is important to realize that there are discrepancies between blood and interstitial glucose concentration, which (1) may impact the quality of the system calibration and thereby the accuracy of the data, (2) may jeopardize the specificity and the sensitivity of hypoglycaemic alarms based on these systems and (3) must be considered in the design of closed-loop insulin delivery systems. The aim of this review is to make the point that the challenge of developing a continuous glucose monitoring system is not only technological, but must also take into account the physiology of glucose in alternate sites where it is sensed.

Keywords: Continuous glucose monitoring, Interstitial glucose, Push-pull phenomenon

Rights & PermissionsPrintExport Cite as

Article Details

Year: 2008
Page: [175 - 180]
Pages: 6
DOI: 10.2174/157339908785294488
Price: $65

Article Metrics

PDF: 9