Abstract
Loss of telomere DNA in normal somatic cells is a major alteration upon ageing. Stem cells and progenitor cells also lose telomere DNA, but at a slower rate than normal cells due to activation of a low level of telomerase activity. Embryonic stem cells exhibit strong telomerase activity, maintain telomere length, and are resistant to DNA damage. In contrast, hematopoietic stem cells, which have weak telomerase activity, are sensitive to DNA damage. The shelterin complex is involved in t-loop formation, a mechanism thought to protect chromosome ends from DNA damage that induces telomere dysfunction. Telomere dysfunction in stem cells brought on by ageing as well as DNA damage has been shown to partake in various age-related diseases. This review illustrates the importance of the telomere end protection mechanism in normal, stem cells and cancer stem cells.
Keywords: Telomere, telomerase, stem cell, DNA damage, anti-cancer drug, cancer stem cell, G-quadruplex
Current Cancer Therapy Reviews
Title: Telomere End Protection in Stem Cells and Cancer Cells
Volume: 4 Issue: 3
Author(s): Hidetoshi Tahara
Affiliation:
Keywords: Telomere, telomerase, stem cell, DNA damage, anti-cancer drug, cancer stem cell, G-quadruplex
Abstract: Loss of telomere DNA in normal somatic cells is a major alteration upon ageing. Stem cells and progenitor cells also lose telomere DNA, but at a slower rate than normal cells due to activation of a low level of telomerase activity. Embryonic stem cells exhibit strong telomerase activity, maintain telomere length, and are resistant to DNA damage. In contrast, hematopoietic stem cells, which have weak telomerase activity, are sensitive to DNA damage. The shelterin complex is involved in t-loop formation, a mechanism thought to protect chromosome ends from DNA damage that induces telomere dysfunction. Telomere dysfunction in stem cells brought on by ageing as well as DNA damage has been shown to partake in various age-related diseases. This review illustrates the importance of the telomere end protection mechanism in normal, stem cells and cancer stem cells.
Export Options
About this article
Cite this article as:
Tahara Hidetoshi, Telomere End Protection in Stem Cells and Cancer Cells, Current Cancer Therapy Reviews 2008; 4 (3) . https://dx.doi.org/10.2174/157339408785294276
DOI https://dx.doi.org/10.2174/157339408785294276 |
Print ISSN 1573-3947 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6301 |
Call for Papers in Thematic Issues
Current progress in Protein Degradation and Cancer Therapy
argeted Protein Degradation is gaining momentum in cancer therapy, it facilitate targeting undruggable proteins, it overcome cancer resistance and avoid undesirable side effects. Thus small molecules degraders have emerged as novel therapeutic strategy. Targeted protein degradation (TPD), the process of eliminating a protein of interest hold a great promise for ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Preface
Current Cancer Drug Targets Design, Synthesis, and Biological Evaluation of New Azole Derivatives as Potent Aromatase Inhibitors with Potential Effects against Breast Cancer
Anti-Cancer Agents in Medicinal Chemistry Physiology of Folic Acid in Health and Disease
Current Drug Metabolism Novel Research Strategies of Benzimidazole Derivatives: A Review
Mini-Reviews in Medicinal Chemistry Relevance of the Salvage Pathway to N-Hexanoylsphingosine Metabolic Downregulation in Human Neurotumor Cells: Implications for Apoptosis
Drug Metabolism Letters Breast Cancer Segmentation Recognition Using Explored DCT-DWT based Compression
Recent Patents on Engineering IgG4 Related Syndrome: Another Multiorgan Disease in the Interest Field of Internal Medicine
Current Pharmaceutical Design Biotherapy for Autoimmune Liver Diseases
Current Pharmaceutical Biotechnology Targeting SKCa Channels in Cancer: Potential New Therapeutic Approaches
Current Medicinal Chemistry Lactose and Casein Cause Changes on Biomarkers of Oxidative Damage and Dysbiosis in an Experimental Model of Multiple Sclerosis
CNS & Neurological Disorders - Drug Targets Tandem One-Pot Synthesis of Indoles Having a Structural Moiety of Propellane
Letters in Organic Chemistry Active Subnetwork GA: A Two Stage Genetic Algorithm Approach to Active Subnetwork Search
Current Bioinformatics Use of Artificial Cell Microcapsule Containing Thalidomide for Treating TNBS-induced Crohn's Disease in Mice
Current Drug Delivery NKT Cell Subsets Can Exert Opposing Effects in Autoimmunity, Tumor Surveillance and Inflammation
Current Immunology Reviews (Discontinued) Sulforaphane Protects Small Intestinal Mucosa From Aspirin/NSAID-Induced Injury by Enhancing Host Defense Systems Against Oxidative Stress and by Inhibiting Mucosal Invasion of Anaerobic Enterobacteria
Current Pharmaceutical Design Elicitation of Immune Responsiveness Against Antigenic Challenge in Age- Related Diseases: Effects of Red Wine Polyphenols
Current Pharmaceutical Design Fe-S Proteins Acting as Redox Switch: New Key Actors of Cellular Adaptive Responses
Current Chemical Biology New Aspects of Regulatory Signaling Pathways and Novel Therapies in Pancreatic Cancer
Current Molecular Medicine New Approaches to Target Cancer Stem Cells: Current Scenario
Mini-Reviews in Medicinal Chemistry Possible Role of NUCB2/nesfatin-1 in Adipogenesis
Current Pharmaceutical Design