Abstract
The TGF-β signaling pathway plays a significant role in various biological phenomena such as cell growth, embryogenesis, differentiation, morphogenesis and apoptosis. Gastrointestinal endodermal stem cells, influenced by TGF- β signals, undergo asymmetric cell division that leads to differentiation into tissue-specific functional cells such as hepatocytes and gut epithelial cells. Disruption of this process results in tissue-specific cancer development. This review illustrates the role of TGF-β signaling in normal and cancer stem cells. Through mouse studies targeting different members of this pathway, investigators will be able to better define mechanisms of malignant progression in order to develop and improve cancer therapeutics.
Keywords: TGF-β, ELF, Smad4, gastrointestinal tract, cancer stem cells
Current Cancer Therapy Reviews
Title: TGF-β Signaling in Gastrointestinal Cancer Stem Cells
Volume: 4 Issue: 3
Author(s): Chohee Yun, Jonathan Mendelson, Young Woo Kim and Lopa Mishra
Affiliation:
Keywords: TGF-β, ELF, Smad4, gastrointestinal tract, cancer stem cells
Abstract: The TGF-β signaling pathway plays a significant role in various biological phenomena such as cell growth, embryogenesis, differentiation, morphogenesis and apoptosis. Gastrointestinal endodermal stem cells, influenced by TGF- β signals, undergo asymmetric cell division that leads to differentiation into tissue-specific functional cells such as hepatocytes and gut epithelial cells. Disruption of this process results in tissue-specific cancer development. This review illustrates the role of TGF-β signaling in normal and cancer stem cells. Through mouse studies targeting different members of this pathway, investigators will be able to better define mechanisms of malignant progression in order to develop and improve cancer therapeutics.
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Cite this article as:
Yun Chohee, Mendelson Jonathan, Kim Woo Young and Mishra Lopa, TGF-β Signaling in Gastrointestinal Cancer Stem Cells, Current Cancer Therapy Reviews 2008; 4 (3) . https://dx.doi.org/10.2174/157339408785294339
DOI https://dx.doi.org/10.2174/157339408785294339 |
Print ISSN 1573-3947 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6301 |
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argeted Protein Degradation is gaining momentum in cancer therapy, it facilitate targeting undruggable proteins, it overcome cancer resistance and avoid undesirable side effects. Thus small molecules degraders have emerged as novel therapeutic strategy. Targeted protein degradation (TPD), the process of eliminating a protein of interest hold a great promise for ...read more
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