Abstract
Chloride channels are involved in many different physiological processes such as cell migration, proliferation and apoptosis. The importance of the CLC family of chloride channels in these cellular functions has been recognized only recently. Infiltration of inflammatory cells, such as eosinophils, T cells, mast cells and neutrophils, is a hallmark of allergy and asthma. Indeed, chronic asthma is associated with widespread damage to the bronchial epithelium, due to excessive apoptosis, and with defective epithelial repair. However, the relationship between the immune cells of allergic airway diseases and chloride channels has not been clearly elucidated. In this review, characteristics of CLC channels are mainly discussed based on their function and presence in different immune cells in airway diseases. Not only are chloride channels involved in the recruitment of immune cells, they also play a role in the activation of these cells. Thus, understanding the role of CLC channels in the immune cells would provide unique insights to the pathophysiologic process of chronic asthma and the means to prevent or reverse the disease.
Keywords: Apoptosis, cell migration, cell proliferation, chloride channels, eosinophils, epithelial cells, macrophages, mast cells, neutrophils, T lymphocytes
Current Molecular Medicine
Title: Chloride Channel Expression and Functional Diversity in the Immune Cells of Allergic Diseases
Volume: 8 Issue: 5
Author(s): Gang Cheng, Ajeeth Ramanathan, Zhifei Shao and Devendra K. Agrawal
Affiliation:
Keywords: Apoptosis, cell migration, cell proliferation, chloride channels, eosinophils, epithelial cells, macrophages, mast cells, neutrophils, T lymphocytes
Abstract: Chloride channels are involved in many different physiological processes such as cell migration, proliferation and apoptosis. The importance of the CLC family of chloride channels in these cellular functions has been recognized only recently. Infiltration of inflammatory cells, such as eosinophils, T cells, mast cells and neutrophils, is a hallmark of allergy and asthma. Indeed, chronic asthma is associated with widespread damage to the bronchial epithelium, due to excessive apoptosis, and with defective epithelial repair. However, the relationship between the immune cells of allergic airway diseases and chloride channels has not been clearly elucidated. In this review, characteristics of CLC channels are mainly discussed based on their function and presence in different immune cells in airway diseases. Not only are chloride channels involved in the recruitment of immune cells, they also play a role in the activation of these cells. Thus, understanding the role of CLC channels in the immune cells would provide unique insights to the pathophysiologic process of chronic asthma and the means to prevent or reverse the disease.
Export Options
About this article
Cite this article as:
Cheng Gang, Ramanathan Ajeeth, Shao Zhifei and Agrawal K. Devendra, Chloride Channel Expression and Functional Diversity in the Immune Cells of Allergic Diseases, Current Molecular Medicine 2008; 8 (5) . https://dx.doi.org/10.2174/156652408785160934
DOI https://dx.doi.org/10.2174/156652408785160934 |
Print ISSN 1566-5240 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5666 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Hepatic PPARs: Their Role in Liver Physiology, Fibrosis and Treatment
Current Medicinal Chemistry Genetic Predictors of Drug Hypersensitivity
Current Pharmaceutical Design The Gut-Brain Axis, Including the Microbiome, Leaky Gut and Bacterial Translocation: Mechanisms and Pathophysiological Role in Alzheimer’s Disease
Current Pharmaceutical Design Gastrointestinal Immune System and Brain Dialogue Implicated in Neuroinflammatory and Neurodegenerative Diseases
Current Molecular Medicine From Nature to Drug Discovery: The Indole Scaffold as a ‘Privileged Structure’
Mini-Reviews in Medicinal Chemistry Resistin-Like Molecule-α Causes Lung Injury in Rats with Acute Pancreatitis by Activating the PI-3K/Akt-NF-κB Pathway and Promoting Inflammatory Cytokine Release
Current Molecular Medicine Evaluation of Topical Black Seed Oil in the Treatment of Allergic Rhinitis
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry Involvement of Orbital Structures in Rheumatic Disease
Current Rheumatology Reviews An Overview on Pyranocoumarins: Synthesis and Biological Activities
Current Organic Chemistry Recent Progress in Chemosensors Using Aldehyde-bearing Fluorophores for the Detection of Specific Analytes and their Bioimaging
Current Medicinal Chemistry Current Understanding of Dietary Polyphenols and their Role in Health and Disease
Current Nutrition & Food Science Macrocyclic Histone Deacetylase Inhibitors
Current Topics in Medicinal Chemistry Effects of [Nphe1]nociceptin(1-13)NH2, [Phe1(CH2-NH)Gly2]nociceptin(1- 13)NH2, and Nocistatin on Nociceptin Inhibited Constrictions of Guinea Pig Isolated Bronchus
Protein & Peptide Letters Selenoproteins and their Role in Oxidative Stress and Inflammation
Current Chemical Biology The Impact of Nanobiotechnology on the Development of New Drug Delivery Systems
Current Pharmaceutical Biotechnology Chemokines: Central Mediators of the Innate Response to Sepsis
Current Immunology Reviews (Discontinued) Can Untargeted Metabolomics Be Utilized in Drug Discovery/Development?
Current Topics in Medicinal Chemistry Clinical Implications of COX-1 and / or COX-2 Inhibition for the Distal Gastrointestinal Tract
Current Pharmaceutical Design Adjuvant and Antigen Delivery Properties of Virosomes
Current Drug Delivery Flow Chemistry to Control the Synthesis of Nano and Microparticles for Biomedical Applications
Current Topics in Medicinal Chemistry