Title: Medical Implications of Benzimidazole Derivatives as Drugs Designed for Targeting DNA and DNA Associated Processes
VOLUME: 15 ISSUE: 18
Author(s):Santanu Bhattacharya and Padmaparna Chaudhuri
Affiliation:Department of Organic Chemistry, Indian Institute of Science, Bangalore 560012, India.
Keywords:Antibacterial, DNA-alkylation, intercalation, major- and minor-groove, transcription factor, polymerase, helicase, topoisomerase
Abstract: Properties of benzimidazole and its derivatives have been studied for over hundred years; special interest of researchers triggered by the fact that 5,6-dimethylbenzimidazole is a component of naturally occurring vitamin B12. Several antihelminthic, antacid and antibacterial drugs are known which have benzimidazole moiety as their essential constituent. Additionally, several bis- and trisbenzimidazole based systems are well-known for their interaction with DNA and interference with several DNA associated processes. This account gives an overview of the benzimidazole based systems and their relevance in medicinal chemistry.
