Advances in Parallel Screening of Drug Candidates

Author(s): Paolo Bergese, Marina Cretich, Claudio Oldani, Giulio Oliviero, Gabriele Di Carlo, Laura E. Depero, Marcella Chiari

Journal Name: Current Medicinal Chemistry

Volume 15 , Issue 17 , 2008

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In the hit to lead process, a drug candidate is selected from a set of potential leads by screening its binding with potential targets. This review focuses on the lead identification assays that employ a bio-chemical or bio-physical test to detect molecular recognition events between proteins and small molecules in a parallel format.These tests require either the lead or the target immobilization followed by incubation with the set of potential interaction partners and detection of a signal related to the target-ligand binding. In the first part of the review the different detection strategies amenable for drug screening are discussed. In the second part, a review of immobilization approaches for leads or targets, allowing the parallel screening of arrays of molecules, is presented.

Keywords: Lead, drug, detection, drug discovery, high throughput screening, small molecule microarrays

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Article Details

Year: 2008
Page: [1706 - 1719]
Pages: 14
DOI: 10.2174/092986708784872366
Price: $65

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