There has been a surge of interest in the therapeutic targeting of the Wnt pathway following the demonstration that it is activated in a wide variety of tumors and that blocking aberrant signaling promoted tumor cell apoptosis or differentiation. This review describes recent therapeutic approaches and discusses potential opportunities for intervention at multiple levels within the Wnt pathway.
Keywords: Wnt, β-catenin, signaling, dysregulation, cancer, therapy
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Published on: 01 March, 2012
Page: [532 - 547]