Similarity Analysis of Protein Sequences Based on the Normalized Relative-Entropy

Author(s): Chun Li, Jun Wang, Yi Zhang

Journal Name: Combinatorial Chemistry & High Throughput Screening
Accelerated Technologies for Biotechnology, Bioassays, Medicinal Chemistry and Natural Products Research

Volume 11 , Issue 6 , 2008

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Based on the classification of 20 amino acids, we reduce a protein primary sequence to six (0,1) sequences. For each of them, two so-called normalized relative-entropies are calculated and thus a 12-D vector is constructed to describe the protein primary sequence. The examination of similarities/dissimilarities among eight different proteins illustrates the utility of the approach.

Keywords: Protein, (0,1)-sequence, normalized relative-entropy

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Article Details

Year: 2008
Page: [477 - 481]
Pages: 5
DOI: 10.2174/138620708784911500
Price: $65

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