Abstract
Magnetic resonance spectroscopy (MRS) has been used for several decades to examine the biochemistry of the myocardium in a non destructive manner. 31P MRS, in particular, has been used to study heart failure. 31P MRS allows for the detection of adenosine triphosphate (ATP), the primary energy source for all energy consuming processes in cardiomyocytes, and phosphocreatine (PCr). Via the creatine kinase (CK) reaction PCr forms the primary ATP buffer in the cell and is involved in transporting the chemical energy from the ATP-producing mitochondria to the ATP-consuming contractile proteins. MRS examination of the failing heart has revealed that PCr, and to a lesser extent, ATP is reduced. These findings have led to the concept that the heart is energy starved. The additional application of 1H MRS has allowed for the detection of total creatine, allowing for in depth examination of the creatine kinase system. Using saturation transfer techniques it is also possible to measure flux through the CK reaction in the intact heart, and the application of this technique has proven that in the failing human heart this flux is reduced. In recent years the study of transgenic animal models by MRS has led to further insights into the role of energy metabolism in heart failure.
Current Pharmaceutical Design
Title: The Application of NMR Spectroscopy for the Study of Heart Failure
Volume: 14 Issue: 18
Author(s): Michiel ten Hove and Stefan Neubauer
Affiliation:
Abstract: Magnetic resonance spectroscopy (MRS) has been used for several decades to examine the biochemistry of the myocardium in a non destructive manner. 31P MRS, in particular, has been used to study heart failure. 31P MRS allows for the detection of adenosine triphosphate (ATP), the primary energy source for all energy consuming processes in cardiomyocytes, and phosphocreatine (PCr). Via the creatine kinase (CK) reaction PCr forms the primary ATP buffer in the cell and is involved in transporting the chemical energy from the ATP-producing mitochondria to the ATP-consuming contractile proteins. MRS examination of the failing heart has revealed that PCr, and to a lesser extent, ATP is reduced. These findings have led to the concept that the heart is energy starved. The additional application of 1H MRS has allowed for the detection of total creatine, allowing for in depth examination of the creatine kinase system. Using saturation transfer techniques it is also possible to measure flux through the CK reaction in the intact heart, and the application of this technique has proven that in the failing human heart this flux is reduced. In recent years the study of transgenic animal models by MRS has led to further insights into the role of energy metabolism in heart failure.
Export Options
About this article
Cite this article as:
Hove ten Michiel and Neubauer Stefan, The Application of NMR Spectroscopy for the Study of Heart Failure, Current Pharmaceutical Design 2008; 14 (18) . https://dx.doi.org/10.2174/138161208784746743
DOI https://dx.doi.org/10.2174/138161208784746743 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
Call for Papers in Thematic Issues
"Tuberculosis Prevention, Diagnosis and Drug Discovery"
The Nobel Prize-winning discoveries of Mycobacterium tuberculosis and streptomycin have enabled an appropriate diagnosis and an effective treatment of tuberculosis (TB). Since then, many newer diagnosis methods and drugs have been saving millions of lives. Despite advances in the past, TB is still a leading cause of infectious disease mortality ...read more
Current Pharmaceutical challenges in the treatment and diagnosis of neurological dysfunctions
Neurological dysfunctions (MND, ALS, MS, PD, AD, HD, ALS, Autism, OCD etc..) present significant challenges in both diagnosis and treatment, often necessitating innovative approaches and therapeutic interventions. This thematic issue aims to explore the current pharmaceutical landscape surrounding neurological disorders, shedding light on the challenges faced by researchers, clinicians, and ...read more
Emerging and re-emerging diseases
Faced with a possible endemic situation of COVID-19, the world has experienced two important phenomena, the emergence of new infectious diseases and/or the resurgence of previously eradicated infectious diseases. Furthermore, the geographic distribution of such diseases has also undergone changes. This context, in turn, may have a strong relationship with ...read more
Melanoma and Non-Melanoma Skin Cancer Treatment: Standard of Care and Recent Advances
In this thematic issue, we aim to provide a standard of care of the diagnosis and treatment of melanoma and non-melanoma skin cancer. The editor will invite authors from different countries who will write review articles of melanoma and non-melanoma skin cancers. The Diagnosis, Staging, Surgical Treatment, Non-Surgical Treatment all ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
The Prevention and Treatment of Delirium in Elderly Patients Following Hip Fracture Surgery
Recent Patents on CNS Drug Discovery (Discontinued) Peroxisome Proliferator-Activated Receptors: Role of Isoform Gamma in the Antineoplastic Effect of Iodine in Mammary Cancer
Current Cancer Drug Targets Vascular Endothelial Growth Factor Receptor 1, a Therapeutic Target in Cancer, Inflammation and Other Disorders
Current Medicinal Chemistry Are Markers of Cardiac Dysfunction Useful in the Assessment of Cardiovascular Risk in Dialysis Patients?
Current Pharmaceutical Design Ganoderma lucidum (Ling-zhi): The Impact of Chemistry on Biological Activity in Cancer
Current Bioactive Compounds Defining Cell Identity by Comprehensive Gene Expression Profiling
Current Medicinal Chemistry Cardiotoxicity Assessment of Drugs Using Human iPS Cell-Derived Cardiomyocytes: Toward Proarrhythmic Risk and Cardio-Oncology
Current Pharmaceutical Biotechnology Membrane and Soluble Forms of Endoglin in Preeclampsia
Current Molecular Medicine Angiotensin II, Cell Proliferation and Angiogenesis Regulator: Biologic and Therapeutic Implications in Cancer
Current Vascular Pharmacology Peptides as Therapeutic Agents or Drug Leads for Autoimmune, Hormone Dependent and Cardiovascular Diseases
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry Lipid-Lowering Drugs Acting at the Level of the Gastrointestinal Tract
Current Pharmaceutical Design The Role of Chymase in Vascular Remodeling and Tissue Fibrosis
Current Hypertension Reviews Inflammatory Markers in Hyperlipidemia: From Experimental Models to Clinical Practice
Current Pharmaceutical Design Amiodarone Hepatotoxicity
Current Vascular Pharmacology Development and Clinical use of Prasugrel and Ticagrelor
Current Pharmaceutical Design New Player on An Old Field; the Keap1/Nrf2 Pathway as a Target for Treatment of Type 2 Diabetes and Metabolic Syndrome
Current Diabetes Reviews Docking-Related Survey on Natural-Product-Based New Monoamine Oxidase Inhibitors and Their Therapeutic Potential
Combinatorial Chemistry & High Throughput Screening Aetiology, Diagnosis and Treatment of Hydrops Foetalis
Current Pediatric Reviews Protein O-GlcNAcylation: A Critical Regulator of the Cellular Response to Stress
Current Signal Transduction Therapy Subject Index To Volume 4
Cardiovascular & Hematological Agents in Medicinal Chemistry