The Imino-pinacol Coupling Reaction

Author(s): Vanessa Faugeroux, Yves Genisson

Journal Name: Current Organic Chemistry

Volume 12 , Issue 9 , 2008

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interest in imino-pinacol coupling arises from the access it offers to 1,2-diamines, a highly valuable class of compounds that have found constant applications in medicinal chemistry and asymmetric catalysis. The present paper intends to cover, from the 60s to present, the different chemical approaches applied to the imino-pinacol coupling, setting each procedure in an historical perspective and delineating general reactivity trends. This review shows that, even though the last 40 years has witnessed an impressive evolution, there is still room for improvement both in terms of flexibility and stereoselectivity.

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Article Details

Year: 2008
Page: [751 - 773]
Pages: 23
DOI: 10.2174/138527208784567188
Price: $58

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