Abstract
The advent of post genomic technologies and their application to biomedical problems resulted in a massive increase the complexity of data generated. This has resulted in the need for more refined statistical and computational methods for analysis of this type of data Through comprehensive analysis and modelling approaches, structures or classes in the data can be defined, denovo predictive biomarkers identified and clinical decision support systems developed. This review seeks to provide an overview of some of the computational methodologies that have been used for data-mining complex high throughput data for the identification of new biomarkers or improvement of existing biomarkers. Given the literature is vast within the area of computational algorithms we seek to present commonly used methods.
Keywords: Biomarkers, ANN, SVM, logistic regression
Current Cancer Therapy Reviews
Title: Computational & Statistical Methodologies to Identify Biomarkers in Cancer
Volume: 4 Issue: 2
Author(s): Graham R. Ball
Affiliation:
Keywords: Biomarkers, ANN, SVM, logistic regression
Abstract: The advent of post genomic technologies and their application to biomedical problems resulted in a massive increase the complexity of data generated. This has resulted in the need for more refined statistical and computational methods for analysis of this type of data Through comprehensive analysis and modelling approaches, structures or classes in the data can be defined, denovo predictive biomarkers identified and clinical decision support systems developed. This review seeks to provide an overview of some of the computational methodologies that have been used for data-mining complex high throughput data for the identification of new biomarkers or improvement of existing biomarkers. Given the literature is vast within the area of computational algorithms we seek to present commonly used methods.
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Cite this article as:
Ball R. Graham, Computational & Statistical Methodologies to Identify Biomarkers in Cancer, Current Cancer Therapy Reviews 2008; 4 (2) . https://dx.doi.org/10.2174/157339408784310043
DOI https://dx.doi.org/10.2174/157339408784310043 |
Print ISSN 1573-3947 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6301 |
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argeted Protein Degradation is gaining momentum in cancer therapy, it facilitate targeting undruggable proteins, it overcome cancer resistance and avoid undesirable side effects. Thus small molecules degraders have emerged as novel therapeutic strategy. Targeted protein degradation (TPD), the process of eliminating a protein of interest hold a great promise for ...read more
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