Abstract
Histone deacetylase (HDAC) inhibitors are a new family of anti-cancer agents currently undergoing clinical investigations for various oncology indications. Their anti-inflammatory activities had been well documented and they appear to be potential therapeutic strategies for various inflammatory diseases. In this review, the anti-inflammatory activities of HDAC inhibitors with emphasis on their potential applications in rheumatoid arthritis (RA) will be summarized. The possible anti-rheumatic mechanisms, including growth arrest in rheumatoid arthritis synovial fibroblasts (RASFs), suppression of pro-inflammatory cytokines or chemokines, anti-angiogenesis as well as protective effects on bone and cartilage destruction will also be discussed. Current literatures strongly imply HDAC inhibitors as innovative anti-rheumatic drug candidates. However, long-term safety is a major concern. Future investigations should focus on identification of molecular anti-rheumatic mechanisms, development of new classes of HDAC inhibitors with better safety and selectivity profiles, combination of HDAC inhibitors with disease modifying anti-rheumatic drugs (DMARDs) and establishment of topical or intraarticular formulations.
Keywords: Epigenetic regulation, histone deacetylase inhibitor, rheumatoid arthritis, growth arrest, pro-inflammatory cytokine, angiogenesis, osteoclastogenesis, nuclear factor kappa-B
Current Pharmaceutical Design
Title: Histone Deacetylase Inhibitors: New Hope for Rheumatoid Arthritis?
Volume: 14 Issue: 8
Author(s): Q. Y. Choo, P. C. Ho and H. S. Lin
Affiliation:
Keywords: Epigenetic regulation, histone deacetylase inhibitor, rheumatoid arthritis, growth arrest, pro-inflammatory cytokine, angiogenesis, osteoclastogenesis, nuclear factor kappa-B
Abstract: Histone deacetylase (HDAC) inhibitors are a new family of anti-cancer agents currently undergoing clinical investigations for various oncology indications. Their anti-inflammatory activities had been well documented and they appear to be potential therapeutic strategies for various inflammatory diseases. In this review, the anti-inflammatory activities of HDAC inhibitors with emphasis on their potential applications in rheumatoid arthritis (RA) will be summarized. The possible anti-rheumatic mechanisms, including growth arrest in rheumatoid arthritis synovial fibroblasts (RASFs), suppression of pro-inflammatory cytokines or chemokines, anti-angiogenesis as well as protective effects on bone and cartilage destruction will also be discussed. Current literatures strongly imply HDAC inhibitors as innovative anti-rheumatic drug candidates. However, long-term safety is a major concern. Future investigations should focus on identification of molecular anti-rheumatic mechanisms, development of new classes of HDAC inhibitors with better safety and selectivity profiles, combination of HDAC inhibitors with disease modifying anti-rheumatic drugs (DMARDs) and establishment of topical or intraarticular formulations.
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Cite this article as:
Choo Y. Q., Ho C. P. and Lin S. H., Histone Deacetylase Inhibitors: New Hope for Rheumatoid Arthritis?, Current Pharmaceutical Design 2008; 14 (8) . https://dx.doi.org/10.2174/138161208784007699
DOI https://dx.doi.org/10.2174/138161208784007699 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
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