A Possible Placental Factor for Preeclampsia: sFlt-1

Author(s): Naoko Kita, Junji Mitsushita

Journal Name: Current Medicinal Chemistry

Volume 15 , Issue 7 , 2008

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Despite its clinical importance, the mechanism of preeclampsia is unclear; however, many believe placental pathology might be related to maternal systemic disease. If this is true, a factor which mediates information from the placenta to the maternal circulation can be hypothesized. Among a variety of such reported factors, soluble fms-like tyrosine kinase-1 (sFlt1) will be the focus of this review. The hypoxic placenta, which is commonly found in preeclampsia, produces sFlt1; furthermore, animal experiments suggest its overexpression leads to preeclampsia-like symptoms.

Keywords: Preeclampsia, sFlt-1, PlGF, VEGF, hypoxia

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Article Details

Year: 2008
Published on: 01 March, 2012
Page: [711 - 715]
Pages: 5
DOI: 10.2174/092986708783885309
Price: $65

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