Peptide Backbone Modifications

Author(s): Uli Kazmaier, Jan Deska

Journal Name: Current Organic Chemistry

Volume 12 , Issue 5 , 2008

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The selective introduction or manipulation of side chains in a peptide represents a severe synthetic challenge. During the last years numerous different approaches towards the targeted modification of small to medium-sized peptides have been developed which should be presented in this review. Focusing on the manipulation of the peptide backbone, procedures concerning selective N-alkylation, C-alkylation and Cequals;O-thionation are described.

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Article Details

Year: 2008
Page: [355 - 385]
Pages: 31
DOI: 10.2174/138527208783743697
Price: $58

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