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Current Pharmaceutical Design

Editor-in-Chief

ISSN (Print): 1381-6128
ISSN (Online): 1873-4286

Heme Oxygenase: A Target Gene for Anti-Diabetic and Obesity

Author(s): N. G. Abraham, P. L. Tsenovoy, J. McClung and G. S. Drummond

Volume 14, Issue 5, 2008

Page: [412 - 421] Pages: 10

DOI: 10.2174/138161208783597371

Abstract

Heme oxygenase-1 (HO-1) is central to the regulation of oxidative injury. The role of increased HO-1 expression and Heme oxygenase (HO) activity in mitigating the detrimental side effect of diabetes is examined. A review of the mechanism(s) of action is included. This may lead to the development of pharmacological and genetic approaches to mitigate the clinical complications associated with the progression of diabetes and obesity.

Keywords: Diabetes, Carbon monoxide, bilirubin, HO-1, Inflamation, TNF, IL-1, adiponectin


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