Heme Oxygenase: A Target Gene for Anti-Diabetic and Obesity

Author(s): N. G. Abraham, P. L. Tsenovoy, J. McClung, G. S. Drummond

Journal Name: Current Pharmaceutical Design

Volume 14 , Issue 5 , 2008

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Heme oxygenase-1 (HO-1) is central to the regulation of oxidative injury. The role of increased HO-1 expression and Heme oxygenase (HO) activity in mitigating the detrimental side effect of diabetes is examined. A review of the mechanism(s) of action is included. This may lead to the development of pharmacological and genetic approaches to mitigate the clinical complications associated with the progression of diabetes and obesity.

Keywords: Diabetes, Carbon monoxide, bilirubin, HO-1, Inflamation, TNF, IL-1, adiponectin

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Article Details

Year: 2008
Page: [412 - 421]
Pages: 10
DOI: 10.2174/138161208783597371

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