Apolipoprotein E Knockout Models

Author(s): Genovefa Kolovou, Katherine Anagnostopoulou, Dimitri P. Mikhailidis, Dennis V. Cokkinos

Journal Name: Current Pharmaceutical Design

Volume 14 , Issue 4 , 2008

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Atherosclerosis is a multifactorial and long-lasting process in humans. Therefore, animal models where more rapid changes occur can be useful for the study of this process. Among such models are the apolipoprotein (apo) E knock out mice. Apo E deficient mice show impaired clearing of plasma lipoproteins and they develop atherosclerosis in a short time. The current review considers lipid metabolism and inflammation as well as nutritional and pharmacological agents affecting atherosclerosis, using the apo E knock out mouse model.

Keywords: Apolipoprotein E, knock out, atherosclerosis

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Article Details

Year: 2008
Page: [338 - 351]
Pages: 14
DOI: 10.2174/138161208783497769
Price: $65

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