Abstract
In the last 50 years, several experimental models of abdominal aortic aneurysms (AAAs) have been described. These models have aided scientists and physicians to understand the pathophysiological mechanisms underlying AAA development and progression. In addition, they have served as means for the development of a number of conservative (such as doxyxycline, marimastat and propranolol) and surgical treatment options for the management of AAAs. In the last few years, experimental models have contributed in the development of novel endovascular techniques for the treatment of AAAs. Animal models of endovascular grafts and percutaneous techniques comprise an essential step for the successful clinical application of these procedures. Additionally, they may comprise part of the training process for vascular surgeons. The different experimental AAA models are briefly presented and their clinical significance is discussed. Experimental models play an essential role in the field of research for the development of more successful therapeutic alternatives for the management of AAAs.
Keywords: Abdominal aortic aneurysms, animal models, experimental, endovascular
Current Pharmaceutical Design
Title: Experimental Models of Abdominal Aortic Aneurysms: An Overview
Volume: 14 Issue: 4
Author(s): Dimitri P. Mikhailidis, Kosmas I. Paraskevas and Despina Perrea
Affiliation:
Keywords: Abdominal aortic aneurysms, animal models, experimental, endovascular
Abstract: In the last 50 years, several experimental models of abdominal aortic aneurysms (AAAs) have been described. These models have aided scientists and physicians to understand the pathophysiological mechanisms underlying AAA development and progression. In addition, they have served as means for the development of a number of conservative (such as doxyxycline, marimastat and propranolol) and surgical treatment options for the management of AAAs. In the last few years, experimental models have contributed in the development of novel endovascular techniques for the treatment of AAAs. Animal models of endovascular grafts and percutaneous techniques comprise an essential step for the successful clinical application of these procedures. Additionally, they may comprise part of the training process for vascular surgeons. The different experimental AAA models are briefly presented and their clinical significance is discussed. Experimental models play an essential role in the field of research for the development of more successful therapeutic alternatives for the management of AAAs.
Export Options
About this article
Cite this article as:
Mikhailidis P. Dimitri, Paraskevas I. Kosmas and Perrea Despina, Experimental Models of Abdominal Aortic Aneurysms: An Overview, Current Pharmaceutical Design 2008; 14 (4) . https://dx.doi.org/10.2174/138161208783497697
DOI https://dx.doi.org/10.2174/138161208783497697 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
Call for Papers in Thematic Issues
"Tuberculosis Prevention, Diagnosis and Drug Discovery"
The Nobel Prize-winning discoveries of Mycobacterium tuberculosis and streptomycin have enabled an appropriate diagnosis and an effective treatment of tuberculosis (TB). Since then, many newer diagnosis methods and drugs have been saving millions of lives. Despite advances in the past, TB is still a leading cause of infectious disease mortality ...read more
Current Pharmaceutical challenges in the treatment and diagnosis of neurological dysfunctions
Neurological dysfunctions (MND, ALS, MS, PD, AD, HD, ALS, Autism, OCD etc..) present significant challenges in both diagnosis and treatment, often necessitating innovative approaches and therapeutic interventions. This thematic issue aims to explore the current pharmaceutical landscape surrounding neurological disorders, shedding light on the challenges faced by researchers, clinicians, and ...read more
Emerging and re-emerging diseases
Faced with a possible endemic situation of COVID-19, the world has experienced two important phenomena, the emergence of new infectious diseases and/or the resurgence of previously eradicated infectious diseases. Furthermore, the geographic distribution of such diseases has also undergone changes. This context, in turn, may have a strong relationship with ...read more
Melanoma and Non-Melanoma Skin Cancer Treatment: Standard of Care and Recent Advances
In this thematic issue, we aim to provide a standard of care of the diagnosis and treatment of melanoma and non-melanoma skin cancer. The editor will invite authors from different countries who will write review articles of melanoma and non-melanoma skin cancers. The Diagnosis, Staging, Surgical Treatment, Non-Surgical Treatment all ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Trends in Nanotechnology Patents Applied to the Health Sector
Recent Patents on Nanotechnology Gender Differences in the Effects of Angiotensin Receptor Blockers on Cardiovascular Disease
Current Pharmaceutical Design MicroRNAs as Early Biomarkers in Obesity and Related Metabolic and Cardiovascular Diseases
Current Pharmaceutical Design The Tree of Sirtuins and the Garden of Cardiovascular Youth
Current Vascular Pharmacology Scaling Down SAGE: from miniSAGE to microSAGE
Current Pharmaceutical Biotechnology Pathophysiology of Cardiovascular Diseases and the Role of Vitamins, and Herbal Extracts in the Reduction of Cardiovascular Risks
Cardiovascular & Hematological Agents in Medicinal Chemistry Abdominal Aortic Aneurysm: What About Screening?
Current Pharmaceutical Design Epidemiology and Costs of Hypertension-related Disorders
Current Pharmaceutical Design Renin-Angiotensin System in Central Nervous System Diseases and its Interaction with COVID-19
Current Medicinal Chemistry Diabetes as a Negative Risk Factor for Abdominal Aortic Aneurysm – Does the Disease Aetiology or the Treatment Provide the Mechanism of Protection?
Current Vascular Pharmacology Mineralocorticoid Receptor Blockade in the Protection of Target Organ Damage
Cardiovascular & Hematological Agents in Medicinal Chemistry Collateral Circulation in Chronic Total Occlusions – an interventional perspective
Current Cardiology Reviews Human Urotensin II Promotes Hypertension and Atherosclerotic Cardiovascular Diseases
Current Medicinal Chemistry Beyond Lipoprotein Receptors: Learning from Receptor Knockouts Mouse Models about New Targets for Reduction of the Atherosclerotic Plaque.
Current Molecular Medicine The Fluctuations of Melatonin and Copeptin Levels in Blood Serum During Surgical Stress Regarding the Pediatric Population
Current Pediatric Reviews Mast Cells: Pivotal Players in Cardiovascular Diseases
Current Cardiology Reviews Newly Diagnosed Dementia and Increased Risk of Hemorrhagic Stroke: A Nationwide Population-based Study
Current Alzheimer Research The Role of Disproportionality Analysis of Pharmacovigilance Databases in Safety Regulatory Actions: a Systematic Review
Current Drug Safety High-accuracy Automated Diagnosis of Parkinson's Disease
Current Medical Imaging Contribution of Platelet-Derived CD40 Ligand to Inflammation, Thrombosis and Neoangiogenesis
Current Medicinal Chemistry