Cell Death in the IPLB-LdFB Insect Cell Line: Facts and Implications

Author(s): D. Malagoli

Journal Name: Current Pharmaceutical Design

Volume 14 , Issue 2 , 2008

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The present review summarizes findings on stress-induced cell death in the IPLB-LdFB insect cell line derived from the larval fat body of the lepidopteron Lymantria dispar. Apoptotic, oncotic and autophagic cell death have been described in these cells as a consequence of oxidative stress or ATP deprivation, and similarities between IPLB-LdFB and mammalian apoptotic pathways have been highlighted. Furthermore, starting from observations in the IPLB-LdFB cells, a link has been surmised between relevance of autophagic cell death and developmental processes in the metazoan taxa.

Keywords: IPLB-LdFB insect cell line, Apoptosis, Oncosis, Autophagic cell death

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Article Details

Year: 2008
Page: [126 - 130]
Pages: 5
DOI: 10.2174/138161208783378752
Price: $65

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