Abstract
Iridoids discussed in this review were chosen based on their anti-inflammatory activity and their having various different bioactivities. Harpagoside is the major iridoid glycoside (0.5-1.6%) in Harpagophytum procumbens, an herbal medicine for rheumatologic conditions. The stem bark of C. ovata is used as an anti-inflammatory drug and catalposide is the main constituent. Geniposide is a main iridoid glucoside of Gardenia jasmoides, 56.2 mg / 500 mg extract. Gardenia fruits are used for the treatment of anti-inflammatory, hepatic and gall bladder diseases. Catalpol, known for its neuroprotective activity, is the major constituent of the roots of Rehmannia glutinosa, which are traditionally used for the treatment of auditory diseases such as tinnitus. Aucubin, which is frequently found as a natural constituent of many traditional medicinal plants, is used in the alleviation of chronic allergic inflammatory disease. PicroLiv, an anti-inflammagen, is a standardized fraction from the root and rhizome of Picrorhiza kurroa containing picrosides I and II and kutkoside. Both aucubin and PicroLiv have potent hepatoprotective activity.
Keywords: Harpagoside, chemopreventive, Genipin, Catalpol, Picrosides I, Catalposide
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry
Title: Bioactivities of Iridoids
Volume: 6 Issue: 4
Author(s): Irene M. Villasenor
Affiliation:
Keywords: Harpagoside, chemopreventive, Genipin, Catalpol, Picrosides I, Catalposide
Abstract: Iridoids discussed in this review were chosen based on their anti-inflammatory activity and their having various different bioactivities. Harpagoside is the major iridoid glycoside (0.5-1.6%) in Harpagophytum procumbens, an herbal medicine for rheumatologic conditions. The stem bark of C. ovata is used as an anti-inflammatory drug and catalposide is the main constituent. Geniposide is a main iridoid glucoside of Gardenia jasmoides, 56.2 mg / 500 mg extract. Gardenia fruits are used for the treatment of anti-inflammatory, hepatic and gall bladder diseases. Catalpol, known for its neuroprotective activity, is the major constituent of the roots of Rehmannia glutinosa, which are traditionally used for the treatment of auditory diseases such as tinnitus. Aucubin, which is frequently found as a natural constituent of many traditional medicinal plants, is used in the alleviation of chronic allergic inflammatory disease. PicroLiv, an anti-inflammagen, is a standardized fraction from the root and rhizome of Picrorhiza kurroa containing picrosides I and II and kutkoside. Both aucubin and PicroLiv have potent hepatoprotective activity.
Export Options
About this article
Cite this article as:
Villasenor M. Irene, Bioactivities of Iridoids, Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry 2007; 6 (4) . https://dx.doi.org/10.2174/187152307783220040
DOI https://dx.doi.org/10.2174/187152307783220040 |
Print ISSN 1871-5230 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-614X |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Safety Issues of Vitamin D Supplementation
Anti-Cancer Agents in Medicinal Chemistry Impact of Computational Structure-Based Predictive Toxicology in Drug Discovery
Combinatorial Chemistry & High Throughput Screening An Evolving Role of Piperazine Moieties in Drug Design and Discovery
Mini-Reviews in Medicinal Chemistry The Impacts of Non-coding RNAs and N<sup>6</sup>-Methyladenosine on Cancer: Past, Present and Future
Current Cancer Drug Targets Estrogen Receptor Polymorphisms: Significance to Human Physiology, Disease and Therapy
Recent Patents on DNA & Gene Sequences The Role of Size in Development of Mucosal Liposome-Lipopeptide Vaccine Candidates Against Group A Streptococcus
Medicinal Chemistry Subject Index To Volume 7
Current Pharmaceutical Design Advanced Glycation and ROS: A Link between Diabetes and Heart Failure
Current Vascular Pharmacology The Causal Relationship Between Passive Smoking and Inflammation on the Development of Cardiovascular Disease: A Review of the Evidence
Inflammation & Allergy - Drug Targets (Discontinued) Impact of Prone Position on Myocardial Perfusion SPECT Interpretation in Women with Suspected Coronary Disease
Current Medical Imaging Exosomes: The Messengers of Health and Disease
Current Neuropharmacology Effects and Perspectives of Chinese Patent Medicines for Tonifying <i>Qi</i> and Promoting Blood Circulation on Patients with Cerebral Infarction
Current Vascular Pharmacology Endothelin-1 Actions on Vascular Smooth Muscle Cell Functions As a Target for the Prevention of Atherosclerosis
Current Vascular Pharmacology Outline of Proteins and Signaling Pathways Involved in Heart Failure
Current Protein & Peptide Science Peripheral Arterial Disease - The Forgotten Risk Factor
Vascular Disease Prevention (Discontinued) Biologic Therapy in Inflammatory and Immunomediated Arthritis: Safety Profile
Current Drug Safety Phytoestrogens and other Botanicals: On the Problems of Evidence-based Evaluation
Recent Patents on Cardiovascular Drug Discovery Fungal Bioactive Compounds in Pharmaceutical Research and Development
Current Bioactive Compounds Advent and Maturation of Regenerative Medicine
Current Stem Cell Research & Therapy NPY Y1 and Y5 Receptor Selective Antagonists as Anti-Obesity Drugs
Current Topics in Medicinal Chemistry