RAGE as a Receptor of HMGB1 (Amphoterin): Roles in Health and Disease

Author(s): Heikki Rauvala, Ari Rouhiainen

Journal Name: Current Molecular Medicine

Volume 7 , Issue 8 , 2007

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HMGB1/Amphoterin is a ubiquitous, highly conserved DNA-binding protein that can be also released to the extracellular space by various cell types. Extracellular HMGB1 regulates migratory responses of several cell types through binding to RAGE that communicates with the cytoskeleton to regulate cell motility. HMGB1- induced cell signalling has been associated with mechanisms of several diseases, including cancer, sepsis, rheumatoid arthritis, stroke and atherosclerosis. This article reviews the evidence linking the functional roles of HMGB1 to RAGE signalling. Furthermore, we discuss the molecular and cellular mechanisms that may explain the roles of HMGB1/RAGE in diverse disease processes.

Keywords: RAGE-binding region, HMGB1 expression, MAPK kinases, inflammation, plasticity

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Article Details

Year: 2007
Page: [725 - 734]
Pages: 10
DOI: 10.2174/156652407783220750
Price: $65

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