Lipases as Modulators of Atherosclerosis in Murine Models

Author(s): Robert J. Brown, Daniel J. Rader.

Journal Name: Current Drug Targets

Volume 8 , Issue 12 , 2007

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Lipoprotein lipase, hepatic lipase, and endothelial lipase are sn-1 lipases that play important roles in the metabolism of plasma lipoproteins. In vitro and in vivo studies suggest that these lipases exhibit both pro- and antiatherogenic properties, which are dependent primarily on their tissue localization. The following chapter reviews the physiology of these lipases, and the consequences of the loss or gain of function for each lipase in modulating atherosclerosis, with emphasis on murine models.

Keywords: Lipase, lipoprotein, aortic lesion, coronary artery disease, atherosclerosis, transgenic mouse, knockout mouse

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Article Details

Year: 2007
Page: [1307 - 1319]
Pages: 13
DOI: 10.2174/138945007783220614
Price: $65

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PDF: 12