Applications of the Combination of Microwave and Parallel Synthesis in Medicinal Chemistry

Author(s): Jesus Alcazar, Gaston Diels, Bruno Schoentjes

Journal Name: Combinatorial Chemistry & High Throughput Screening
Accelerated Technologies for Biotechnology, Bioassays, Medicinal Chemistry and Natural Products Research

Volume 10 , Issue 10 , 2007

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The blending of microwave heating and parallel chemistry is a logical consequence of the significant rate enhancement and higher product yield afforded by microwave technology and the increase in productivity afforded by combinatorial chemistry. For this reason, this combination has become increasingly popular in the organic chemistry community. The current review highlights the application of this approach as a way to increase the rate of analogue synthesis in medicinal chemistry.

Keywords: opioid receptor agonists, Piperazine Derivatives, Tropanylidene Derivatives, HIV-1 protease, malaria parasites, Obesity

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Article Details

Year: 2007
Page: [918 - 932]
Pages: 15
DOI: 10.2174/138620707783220383
Price: $65

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