Title: Mechanisms of Intrinsic and Acquired Resistance to EGFR Inhibitors
VOLUME: 3 ISSUE: 4
Author(s):Floriana Morgillo, Giampaolo Tortora and Fortunato Ciardiello
Affiliation:Dipartimento Medico-Chirurgico di Internistica Clinica e Sperimentale“F. Magrassi e A. Lanzara”,Seconda Universita degli Studi di Napoli, Italy; Via S. Pansini 5,80131 Napoli, Italy.
Keywords:EGFR, Monoclonal antibody, Tyrosine kinase inhibitor, resistance
Abstract: In the last decades the epidermal growth factor receptor (EGFR), which is frequently expressed in a variety of epithelial tumors, has been a major target of molecular anticancer therapy.
