Functional Genomics and NMR Spectroscopy

Author(s): Robert Powers

Journal Name: Combinatorial Chemistry & High Throughput Screening
Accelerated Technologies for Biotechnology, Bioassays, Medicinal Chemistry and Natural Products Research

Volume 10 , Issue 8 , 2007

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The recent success of the human genome project and the continued accomplishment in obtaining DNA sequences for a vast array of organisms is providing an unprecedented wealth of information. Nevertheless, an abundance of the proteome contains hypothetical proteins or proteins of unknown function, where high throughput approaches for genome- wide functional annotation (functional genomics) has evolved as the necessary next step. Nuclear magnetic resonance spectroscopy is playing an important role in functional genomics by providing information on the structure of protein and protein-ligand complexes, from metabolite fingerprinting and profiling, from the analysis of the metabolome, and from ligand affinity screens to identify chemical probes.

Keywords: NMR, functional genomics, NMR high throughput screens, protein-ligand binding, protein-ligand co-structures, structural biology, structural genomics, NMR metabolomics, chemical proteomics, protein structure initiative

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Article Details

Year: 2007
Page: [676 - 697]
Pages: 22
DOI: 10.2174/138620707782507331
Price: $65

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