Abstract
This volume recognizes the critical and central role of the mouse in experimental atherosclerosis pathology. Atherosclerosis is a complex and chronic inflammation [1] in which multiple modulating factors may play a role. Its chronicity and complexity make it very difficult to study the detailed mechanisms of atherogenesis in unregulated human populations. The search for atherogenic mechanisms requires a model in which these mechanisms simulate those inferred in humans, and in which controlled experiments may be conducted in a reasonable timeframe and at manageable expense. The mouse recommends itself as a small animal model with a short life span in which atherosclerosis similar in character to human atherosclerosis may be induced under controlled conditions. With the development of genetic models of atherosclerosis the mouse has become a very accessible model, especially with the very large genetic data base about this species in relation to human biology that has become available [1].
Keywords: Lipid, HDL, lipoprotein, mouse strain, metabolism
Current Drug Targets
Title: Overview of Murine Atherosclerosis Series
Volume: 8 Issue: 11
Author(s): Godfrey S. Getz
Affiliation:
Keywords: Lipid, HDL, lipoprotein, mouse strain, metabolism
Abstract: This volume recognizes the critical and central role of the mouse in experimental atherosclerosis pathology. Atherosclerosis is a complex and chronic inflammation [1] in which multiple modulating factors may play a role. Its chronicity and complexity make it very difficult to study the detailed mechanisms of atherogenesis in unregulated human populations. The search for atherogenic mechanisms requires a model in which these mechanisms simulate those inferred in humans, and in which controlled experiments may be conducted in a reasonable timeframe and at manageable expense. The mouse recommends itself as a small animal model with a short life span in which atherosclerosis similar in character to human atherosclerosis may be induced under controlled conditions. With the development of genetic models of atherosclerosis the mouse has become a very accessible model, especially with the very large genetic data base about this species in relation to human biology that has become available [1].
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Cite this article as:
Getz S. Godfrey, Overview of Murine Atherosclerosis Series, Current Drug Targets 2007; 8 (11) . https://dx.doi.org/10.2174/138945007782403865
DOI https://dx.doi.org/10.2174/138945007782403865 |
Print ISSN 1389-4501 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5592 |
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