The Analysis and Crystallographic Characterization of 20-Hydroxyecdysone.

Author(s): Maria Bathori, Alajos Kalman, Gyula Argay, Huba Kalasz

Journal Name: Current Medicinal Chemistry

Volume 7 , Issue 12 , 2000

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20-Hydroxyecdysone (20E) is an insect molting hormone that is also widely spread in various plants. Many chromatographic methods can be used to identify and/or determine 20E content in samples of biological origin and various spectroscopic methods serve to identify its structural elements. We have utilized X-ray crystallography to reveal the stereostructures of 20E. Our data demonstrates that 20E exists in two different crystalline forms that are both orthorhombic modifications. One form is homo-molecular, with a limited freedom of internal rotation of the side chain around the C23-C24 bond and the other, which is a clathrate formed with methanol and water, which minimize the conformational freedom of the side chain.

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Article Details

Year: 2000
Page: [1305 - 1312]
Pages: 8
DOI: 10.2174/0929867003374165
Price: $65

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