Rational Drug Design and High-Throughput Techniques for RNA Targets

Author(s): Thomas Hermann, Eric Westhof

Journal Name: Combinatorial Chemistry & High Throughput Screening
Accelerated Technologies for Biotechnology, Bioassays, Medicinal Chemistry and Natural Products Research

Volume 3 , Issue 3 , 2000

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RNA molecules are the only known molecules which possess the double property of being depository of genetic information, like DNA, and of displaying catalytic activities, like protein enzymes. RNA molecules intervene in all steps of gene expression and in many other biological activities. Like proteins, RNAs achieve those biological functions by adopting intricate three-dimensional folds and architectures. Further, as in protein sequences, RNA sequences contain signatures specific for three-dimensional motifs which participate in recognition and binding. In regulatory pathways, RNA molecules exist in equilibria between transient structures differentially stabilized by effectors such as proteins or cofactors. Therefore, RNA molecules display their potential as drug targets on different levels, namely in three-dimensional folds, in structural equilibria and in RNA-protein interfaces. Several examples will be described together with the already available techniques for combinatorial synthesis and high-t hroughput screening of potential drug and target RNA molecules.

Keywords: Drug design, High throughput, RNA targets, RNA molecules, Expressed sequence tags

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Article Details

Year: 2000
Published on: 01 March, 2012
Page: [219 - 234]
Pages: 16
DOI: 10.2174/1386207003331652
Price: $65

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