Functionalized Porous Silica Microspheres as Scavengers in Parallel Synthesis

Title: Functionalized Porous Silica Microspheres as Scavengers in Parallel Synthesis

Volume: 3 Issue: 2

Author(s): Lorin A. Thompson, Andrew P. Combs, George L. Trainor, Qunjie Wang, Timothy J. Langlois and Joseph J. Kirkland

Affiliation:

Keywords: Porus silica micropheres, Scavengers, Parallel synthesis, Calypso, Synthesis

Abstract: The use of solid scavengers in parallel solution-phase organic synthesis is an effective method for work-up and purification. Functionalized macroreticular or gel-form polystyrene particles are generally used for scavenging applications, how ever these materials have some limitations. We have developed new scavenging reagents based on ultrapure silica microspheres displaying a variety of functional groups useful for sequestering impurities from reaction products. These materials are easy to handle, have excellent mass-transfer properties, and are efficient scavengers in both polar and nonpolar organic solvents. The properties of these materials were tailored specifically to fit the needs of a medicinal chemist employing parallel synthesis techniques in current commercial equipment. Results are presented from head-to-head comparisons with conventional scavengers in tests designed to demonstrate the versatility of these new materials.

Cite this article as:

Thompson A. Lorin, Combs P. Andrew, Trainor L. George, Wang Qunjie, Langlois J. Timothy and Kirkland J. Joseph, Functionalized Porous Silica Microspheres as Scavengers in Parallel Synthesis, Combinatorial Chemistry & High Throughput Screening 2000; 3 (2) . https://dx.doi.org/10.2174/1386207003331670