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Current Gene Therapy

Editor-in-Chief

ISSN (Print): 1566-5232
ISSN (Online): 1875-5631

T Lymphocytes as Targets of Gene Transfer with Moloney-Type Retroviral Vectors

Author(s): F. A. Ayuk, A. R. Zander and B. Fehse

Volume 1, Issue 4, 2001

Page: [325 - 337] Pages: 13

DOI: 10.2174/1566523013348274

Price: $65

Abstract

Peripheral T lymphocytes are a target of choice for many gene therapeutic strategies. Retrovirus-mediated transduction allows genomic integration and long-term expression of transgenes in target cells. Over many years, low transduction efficiency into primary T lymphocytes has limited clinical application of existing protocols. Recently, gene transfer rates > 50% have been achieved facilitating clinical studies. More attention is thus being focused on the ability of gene-modified cells to carry out innate as well as conferred functions in vivo and the influence of culture conditions, retroviral vector and host response thereon.


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