T Lymphocytes as Targets of Gene Transfer with Moloney-Type Retroviral Vectors

Author(s): F. A. Ayuk, A. R. Zander, B. Fehse

Journal Name: Current Gene Therapy

Volume 1 , Issue 4 , 2001

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Peripheral T lymphocytes are a target of choice for many gene therapeutic strategies. Retrovirus-mediated transduction allows genomic integration and long-term expression of transgenes in target cells. Over many years, low transduction efficiency into primary T lymphocytes has limited clinical application of existing protocols. Recently, gene transfer rates > 50% have been achieved facilitating clinical studies. More attention is thus being focused on the ability of gene-modified cells to carry out innate as well as conferred functions in vivo and the influence of culture conditions, retroviral vector and host response thereon.

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Article Details

Year: 2001
Page: [325 - 337]
Pages: 13
DOI: 10.2174/1566523013348274
Price: $65

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