Epidermal Growth Factor Receptor as a Target: Recent Developments in the Search for Effective New Anti-Cancer Agents

Author(s): L. K. Seymour

Journal Name: Current Drug Targets

Volume 2 , Issue 2 , 2001

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A number of cancer chemotherapeutics targeting the epidermal growth factor receptor (EGFR) are in development. These compounds were designed to either bind to the EGFR or inhibit signal transduction after receptor activation. Classes of inhibitory compounds include small molecules and humanized monoclonal antibodies. Many of these compounds are relatively far advanced in development. Proof of principle, with evidence of anti-tumour activity and inhibition of EGFR activation phosphorylation, has already been demonstrated in some instances. Although these new compounds offer exciting opportunities, they bring with them real challenges in terms of the selection of appropriate trial designs as well as surrogate endpoints.

Keywords: epidermal growth factor, receptor (EGFR), Tumourigenesis, Anilino-quinazoline, Quinazoline, Pyrrolo-pyrimidine, Monoclonal antibody

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Article Details

Year: 2001
Page: [117 - 133]
Pages: 17
DOI: 10.2174/1389450013348722
Price: $65

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