Role of the NF-kB Pathway in the Pathogenesis of Human Disease States

Author(s): Yumi Yamamoto, Richard B. Gaynor

Journal Name: Current Molecular Medicine

Volume 1 , Issue 3 , 2001

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The NF-kB family consists of a group of inducible transcription factors which regulate immune and inflammatory responses and protect cells from undergoing apoptosis in response to cellular stress. A number of signal transduction cascades can activate the NF-kB pathway to result in the translocation of the NF-kB proteins from the cytoplasm to the nucleus where they activate the expression of specific cellular genes. In this review, we discuss cellular genes which are regulated by NF-kB and disease states which are associated with constitutive activation of the NF-kB pathway. Strategies to prevent prolonged activation of the NF-kB pathway are also discussed.

Keywords: NF-kB, Pathogenesis, apoptosis, NF-kB proteins, including interleukin 1b (IL-1b), tumor necrosis factor(TNFa), nitric oxide synthase(iNOS), oxide (NO), cyclo-oxygenase (COX-2), (cIAP1, cIAP2, IXAP)

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Article Details

Year: 2001
Published on: 01 March, 2012
Page: [287 - 296]
Pages: 10
DOI: 10.2174/1566524013363816
Price: $65

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