Abstract
Proteins of the Bowman-Birk inhibitor family of serine proteinase inhibitors interact with the enzymes they inhibit via an exposed surface loop that adopts the canonical proteinase inhibitory conformation. The resulting non-covalent complex renders the proteinase inactive. This inhibition mechanism is common for the majority of serine proteinase inhibitor proteins and many analogous examples are known. A particular feature of the Bowman-Birk inhibitor protein, however, is that the interacting loop is a particularly well-defined disulfide-linked short b-sheet region. Moreover, synthetic peptides based on this region keep the same structure as the corresponding part of the full sized protein and also retain inhibitory activity. This review describes the background to inhibition by Bowman-Birk inhibitor proteins (and derived peptides) and shows how peptides based on the reactive site can be manipulated in order to generate potent proteinase inhibitors with redirected specificities.
Keywords: Synthetic Peptide, Bowman-Birk Inhibitor Protein, Bowman-Birk inhibitor (BBI), Inhibition, Structural Analysis, Norleucine
Current Medicinal Chemistry
Title: Synthetic Peptide Mimics of the Bowman-Birk Inhibitor Protein
Volume: 8 Issue: 8
Author(s): Jeffrey D. McBride and Robin J. Leatherbrrow
Affiliation:
Keywords: Synthetic Peptide, Bowman-Birk Inhibitor Protein, Bowman-Birk inhibitor (BBI), Inhibition, Structural Analysis, Norleucine
Abstract: Proteins of the Bowman-Birk inhibitor family of serine proteinase inhibitors interact with the enzymes they inhibit via an exposed surface loop that adopts the canonical proteinase inhibitory conformation. The resulting non-covalent complex renders the proteinase inactive. This inhibition mechanism is common for the majority of serine proteinase inhibitor proteins and many analogous examples are known. A particular feature of the Bowman-Birk inhibitor protein, however, is that the interacting loop is a particularly well-defined disulfide-linked short b-sheet region. Moreover, synthetic peptides based on this region keep the same structure as the corresponding part of the full sized protein and also retain inhibitory activity. This review describes the background to inhibition by Bowman-Birk inhibitor proteins (and derived peptides) and shows how peptides based on the reactive site can be manipulated in order to generate potent proteinase inhibitors with redirected specificities.
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Cite this article as:
McBride D. Jeffrey and Leatherbrrow J. Robin, Synthetic Peptide Mimics of the Bowman-Birk Inhibitor Protein, Current Medicinal Chemistry 2001; 8 (8) . https://dx.doi.org/10.2174/0929867013372832
DOI https://dx.doi.org/10.2174/0929867013372832 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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