Farnesyl Protein Transferase Inhibition: A Novel Approach to Anti-tumor

Title: Farnesyl Protein Transferase Inhibition: A Novel Approach to Anti-tumor

VOLUME: 8 ISSUE: 12

Author(s):A. K. Ganguly, R. J. Doll and V.M. Girijavallabhan

Affiliation:Stevens Institute ofTechnology, Castle Point on Hudson, Hoboken, N.J. 07030, USA

Keywords:Farnesyl Protein Transferase Inhibition, Anti-tumor Therapy, farnesyl protein transferase, Farnesylation, Geranlylgeranylation, carboxymethyl transferase, FPT Enzyme Assay, COS Assay, Pharmacokinetic Assay (PK), Potent FPT Inhibitors

Abstract: Farnesyl protein transferase (FPT) inhibition is an interesting and promising approach to non-cytotoxic anticancer therapy. Research in this area has resulted in several orally active compounds that are currently in clinical evaluation. This review focuses on FPT inhibitors in clinical trials and concentrates on the benzocycloheptapyridine class, with details on the discovery and development of SCH 66336, currently in Phase II clinical trials.

Cite this article as:

A. K. Ganguly, R. J. Doll and V.M. Girijavallabhan, “ Farnesyl Protein Transferase Inhibition: A Novel Approach to Anti-tumor”, Current Medicinal Chemistry (2001) 8: 1419. https://doi.org/10.2174/0929867013372021

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