On-line Sample Preparation for High Throughput Reversed-phase LC / MS Analysis of Combinatorial Chemistry Libraries.

Author(s): Liang Tang, William. L. Fitch, Peter Smith, David Tumelty, Kathy Cao, Steven W. Ferla

Journal Name: Combinatorial Chemistry & High Throughput Screening
Accelerated Technologies for Biotechnology, Bioassays, Medicinal Chemistry and Natural Products Research

Volume 4 , Issue 3 , 2001

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An on-line sample preparation method utilizing a time-programmed autosampler is described for high throughput liquid chromatography / mass spectrometry (LC / MS). This approach is particularly helpful for the LC / MS analysis of samples which require solvents incompatible with HPLC in the sample preparation process. The on-line sample preparation approach minimizes a bottleneck in throughput and improves sample recovery under some circumstances.

Keywords: High Throughput Reversed, Combinatorial Chemistry Libraries, liquid chromatography, Reversed Phase HPLC Columns, dioctyl phthalate, CTC syringe, TentaGel

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Article Details

Year: 2001
Page: [287 - 293]
Pages: 7
DOI: 10.2174/1386207013331110
Price: $65

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