Recent Developments in the Combinatorial Synthesis of Nitrogen Heterocycles Using Solid Phase Technology

Title: Recent Developments in the Combinatorial Synthesis of Nitrogen Heterocycles Using Solid Phase Technology

Volume: 4 Issue: 1

Author(s): P.M.S. Chauhan and Sanjay K. Srivastava

Affiliation:

Keywords: Combinatorial Synthesis, Nitrogen hetrocycle, azepanes, diisopropylcarbodiimide, amino resin, cinnamides, cinnolines, polymer bound

Abstract: Recognizing the potential of combinatorial chemistry to accelerate drug discovery and development, most pharmaceutical and related industries are seriously looking towardcombinatorial synthesis of compounds in order to facilitate the identification of ‘lead’ molecules. In particular, solid phase synthesis is the core technology for combinatorial chemistry and is widely used for generating libraries of structurally related compounds. Since many drugs contain the nitrogen heterocylic component and since heterocycles posses a high order of structural diversity, a precise overview of recent progress in the combinatorial synthesis of nitrogen heterocycles using solid phase methodology would be useful. Since the progress in solid phase synthesis of organic molecules has been reviewed regularly from 1992 to 1998, only the development of solid phase combinatorial synthetic approaches of small nitrogen heterocylces since 1999 will be reviewed here. This review describes the solid phase synthesis of azepanes, benzodiazepines, benzimidazoles, benzothiazepines, cinnolines, indolizines, beta lactams, oxazepins, oxazoles including benzisooxazoles, hydantoins, piperidines, pyrimidines, pyrazolones, quinolones, trizolopyridazines and thiazoles.

Cite this article as:

Chauhan P.M.S. and Srivastava K. Sanjay, Recent Developments in the Combinatorial Synthesis of Nitrogen Heterocycles Using Solid Phase Technology, Combinatorial Chemistry & High Throughput Screening 2001; 4 (1) . https://dx.doi.org/10.2174/1386207013331327