Syntheses and Effect of Bombesin-Fragment6-14 and its Four Analogues on Food Intake in Rats

Author(s): T. Abiko, Y. Kimura

Journal Name: Current Pharmaceutical Biotechnology

Volume 2 , Issue 2 , 2001

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A nonapeptide, H-Asn-Gln-Trp-Ala-Val-Gly-His-Leu-Met-NH2 , corresponding to amino acids 6 to 14 of bombesin and its four analogues were synthesized by a solid-phase method and were tested for their comparative effect on reducing activity on food intake using male Wistar rats. The synthetic bombesin-fragment6- 14 showed reducing effect on food intake using male Wistar rats. Of the synthetic analogues, [Phe(4F)13 ]bombesin-fragment6-14 exhibited the most potent effect. The reducing effect on food intake of [Sar 11 ]bombesin-fragment6-14 was lower than that of our synthetic bombesin-fragment6-14, but the other two analogues, [beta Ala11]bombesin-fragment6-14 and [1-Nal8 ]bombesin-fragment6-14 showed no reducing effect on food intake in rats.

Keywords: Bombesin-Fragment6-14, Food Intake, nonapeptide, H-Asn-Gln-Trp-Ala-Val-Gly-His-Leu-Met-NH2, SOLID-PHASE PEPTIDE SYNTHESIS

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Article Details

Year: 2001
Page: [201 - 207]
Pages: 7
DOI: 10.2174/1389201013378752
Price: $65

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