Phage Display as a Tool for Protease Ligand Discovery

Andrew   E.   Nixon

Abstract

Proteolytic enzymes have been implicated as the pathological agent in a number of disease states. For this reason proteases are attractive therapeutic targets. Phage display of peptide libraries can be used to identify peptides that may be used either directly as inhibitors or serve as leads in the generation of prodrugs and peptidomimetics.

Keywords: Phage Display, Protease Ligand, peptidomimetics, Plasma kallikrein, chymotrypsin, allosteric mechanism