DNA-binding Antitumor Agents: from Pyrimido[5,6,1-de]acridines to Other Intriguing Classes of Acridine Derivatives

Author(s): Ippolito Antonini

Journal Name: Current Medicinal Chemistry

Volume 9 , Issue 18 , 2002

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Abstract:

In the field of antitumor DNA-binding agents, the class of acridine derivatives play an important role either as number of compounds or as importance of their anticancer properties. We have synthesized a number of acridine derivatives as potential antitumor drugs, in which the chromophore is fully or partially constituted by acridine or by 9-acridone ring systems: from the pyrimido[5,6,1-de]acridines, to the pyrimido[4,5,6-kl]acridines, the bis(amine-functionalized) 9-acridone-4-carboxamides, the bis(amine-functionalized) acridine-4-carboxamides, and the pyrazolo[3,4,5- kl]acridine-5-carboxamides. In the present revue we will describe the rational design, the synthesis, and the salient biological characteristics of these classes of acridine derivatives.

Keywords: dna-binding, acridine derivatives, salient biological characteristics, dna intercalation, physicochemical properties, doxorubicin resistant cell line, synthetic approach

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Article Details

VOLUME: 9
ISSUE: 18
Year: 2002
Page: [1701 - 1716]
Pages: 16
DOI: 10.2174/0929867023369268
Price: $65

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