Structure-Activity Relationships in The Acronycine Series

Author(s): Sylvie Michel, Elisabeth Seguin, Francois Tillequin

Journal Name: Current Medicinal Chemistry

Volume 9 , Issue 18 , 2002


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Abstract:

Acronycine is active against a broad spectrum of solid tumors. Structure activity relationships demonstrated the crucial role of the 1,2-double bond. A hypothesis of bioactivation into 1,2-epoxide led to the development of a series of 1,2- dihydroxy-1,2-dihydroacronycine and 1,2-dihydroxy-1,2-dihydrobenzo[b]acronycine diesters that exhibited an increased potency when compared with the parent compound.

Keywords: acronycine, solid tumors, increased potency, antitumor activity, murine leukemia cell line, cytotoxic activity, catalytic osmic oxidation, enlarged spectrum

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Article Details

VOLUME: 9
ISSUE: 18
Year: 2002
Page: [1689 - 1700]
Pages: 12
DOI: 10.2174/0929867023369213
Price: $65

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