Development of DNA Topoisomerase II-Mediated Anticancer Agents, 3-(9- Acridinylamino)-5-hydroxymethylanilines (AHMAs) and Related Compounds

Author(s): Su Tsann-Long

Journal Name: Current Medicinal Chemistry

Volume 9 , Issue 18 , 2002


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Abstract:

A series of potential topoisomerase II-mediated anticancer 9-anilinoacridine derivatives, which are designed to avoid bio-oxidation and possessed long duration of drug action, is reviewed. Among these agents, 3-(9-acridinylamino)-5- hydroxymethylaniline (AHMA) derivatives and their alkylcarbamates have been investigated and developed for potential clinical application.

Keywords: topoisomerase II, anticancer agents, bio-oxidation, potential clinical application, antitumor acridines, human leukemic ccrfcem cells, computer modelling, sar studies, supercoiled dna

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Article Details

VOLUME: 9
ISSUE: 18
Year: 2002
Page: [1677 - 1688]
Pages: 12
DOI: 10.2174/0929867023369231
Price: $65

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