Abstract
Organic structures with fluorine atom are slightly diffuse in nature. Starting 80s researchers have discovered that the selective introduction of fluorine into biologically active molecules exercised an influence on activity. So an important endeavour in drug design have been described and numerous compounds incorporating fluorine as either a bioisosteric replacement for hydrogen or an isoelectronic replacement for the hydroxyl group have been reported. Parallely, an enormous literature on anthracyclines exists, a class of compounds used in clinical since 70s, as antitumor drugs. Unfortunately, the anthracyclines are known as well for several toxical effects that frequently condition the clinical use. In the last decade a lot of anthracycline derivatives has been described in which has been introduced a fluorine atom in different position of molecule. This review wishes to represent an updated collection of compounds with anthracycline structure where a fluorine atom has been introduced on aglycon or / and sugar moiety. Together with the chemical structures, the synthetic indications are furnished and succinct explanations of biological activity are summarised (if available).
Keywords: Fluorinated Anthracyclines, demethoxydaunorubicin, OXYAGLYCONE, IDARUBICIN, eukaryotic topoisomerase, DAUNO derivatives, Multidrug Resistance (MDR)
Current Medicinal Chemistry
Title: Fluorinated Anthracyclines: Synthesis and Biological Activity
Volume: 9 Issue: 6
Author(s): Giuseppe Giannini
Affiliation:
Keywords: Fluorinated Anthracyclines, demethoxydaunorubicin, OXYAGLYCONE, IDARUBICIN, eukaryotic topoisomerase, DAUNO derivatives, Multidrug Resistance (MDR)
Abstract: Organic structures with fluorine atom are slightly diffuse in nature. Starting 80s researchers have discovered that the selective introduction of fluorine into biologically active molecules exercised an influence on activity. So an important endeavour in drug design have been described and numerous compounds incorporating fluorine as either a bioisosteric replacement for hydrogen or an isoelectronic replacement for the hydroxyl group have been reported. Parallely, an enormous literature on anthracyclines exists, a class of compounds used in clinical since 70s, as antitumor drugs. Unfortunately, the anthracyclines are known as well for several toxical effects that frequently condition the clinical use. In the last decade a lot of anthracycline derivatives has been described in which has been introduced a fluorine atom in different position of molecule. This review wishes to represent an updated collection of compounds with anthracycline structure where a fluorine atom has been introduced on aglycon or / and sugar moiety. Together with the chemical structures, the synthetic indications are furnished and succinct explanations of biological activity are summarised (if available).
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Cite this article as:
Giannini Giuseppe, Fluorinated Anthracyclines: Synthesis and Biological Activity, Current Medicinal Chemistry 2002; 9 (6) . https://dx.doi.org/10.2174/0929867023370806
DOI https://dx.doi.org/10.2174/0929867023370806 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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