Glycoconjugate Libraries Accessed by Multicomponent Reactions

Author(s): Oswald Lockhoff, Isabelle Frappa

Journal Name: Combinatorial Chemistry & High Throughput Screening
Accelerated Technologies for Biotechnology, Bioassays, Medicinal Chemistry and Natural Products Research

Volume 5 , Issue 5 , 2002

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Abstract:

Glycobiology opens a wide field for new therapeutic approaches. However, the complexity and unavailability of various carbohydrate test compounds has excluded this class of natural products from modern screening systems. Alternatively, glycomimetics are considered to be more drug-like candidates for development. By means of multicomponent condensations (MCCs) utilizing suitable carbohydrate synthons, rapid and effective access to glycoconjugate libraries can be obtained. The flexibility of MCCs allows the assembly of diverse carbohydrate containing libraries. It may be assumed that MCCs containing carbohydrate moieties will play an important role in glycomimetic chemistry and biology.

Keywords: glycoconjugate libraries, glycobiology, multicomponent reactions

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Article Details

VOLUME: 5
ISSUE: 5
Year: 2002
Page: [361 - 372]
Pages: 12
DOI: 10.2174/1386207023330219
Price: $65

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