Abstract
Glycobiology opens a wide field for new therapeutic approaches. However, the complexity and unavailability of various carbohydrate test compounds has excluded this class of natural products from modern screening systems. Alternatively, glycomimetics are considered to be more drug-like candidates for development. By means of multicomponent condensations (MCCs) utilizing suitable carbohydrate synthons, rapid and effective access to glycoconjugate libraries can be obtained. The flexibility of MCCs allows the assembly of diverse carbohydrate containing libraries. It may be assumed that MCCs containing carbohydrate moieties will play an important role in glycomimetic chemistry and biology.
Keywords: glycoconjugate libraries, glycobiology, multicomponent reactions
Combinatorial Chemistry & High Throughput Screening
Title: Glycoconjugate Libraries Accessed by Multicomponent Reactions
Volume: 5 Issue: 5
Author(s): Oswald Lockhoff and Isabelle Frappa
Affiliation:
Keywords: glycoconjugate libraries, glycobiology, multicomponent reactions
Abstract: Glycobiology opens a wide field for new therapeutic approaches. However, the complexity and unavailability of various carbohydrate test compounds has excluded this class of natural products from modern screening systems. Alternatively, glycomimetics are considered to be more drug-like candidates for development. By means of multicomponent condensations (MCCs) utilizing suitable carbohydrate synthons, rapid and effective access to glycoconjugate libraries can be obtained. The flexibility of MCCs allows the assembly of diverse carbohydrate containing libraries. It may be assumed that MCCs containing carbohydrate moieties will play an important role in glycomimetic chemistry and biology.
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Cite this article as:
Lockhoff Oswald and Frappa Isabelle, Glycoconjugate Libraries Accessed by Multicomponent Reactions, Combinatorial Chemistry & High Throughput Screening 2002; 5 (5) . https://dx.doi.org/10.2174/1386207023330219
DOI https://dx.doi.org/10.2174/1386207023330219 |
Print ISSN 1386-2073 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5402 |
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