Cancer-Homing Toxins

Author(s): H. C. Ng, H. E. Khoo

Journal Name: Current Pharmaceutical Design

Volume 8 , Issue 22 , 2002

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Cancer-homing toxins are a group of man-made cytotoxic molecules targeting cancer cells. In the past decade they have demonstrated potential as cancer therapeutics. These molecules contain a toxin, natural or usually derivatized, connected to a cancerhoming module, such as a monoclonal antibody or growth factor or their derivatives. Various cancer-homing toxins have been designed and tested in cell-lines, animalmodels and clinical trials. We review some of these data and discuss ways to better design cancer-homing toxins in the light of advances in cancer genomics, antibodyengineering techniques and computational algorithms.

Keywords: Downregulation, Toxins, Targeted-therapy, Cancer, Vascular-leak syndrome, Drug- design, Super-antigen, Clinicaltrials

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Article Details

Year: 2002
Page: [1973 - 1985]
Pages: 13
DOI: 10.2174/1381612023393477
Price: $65

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