Abstract
Combinatorial chemistry has become a dramatically useful tool for the development of new medicinal agents. In the search to discover a novel and effective lead for the treatment of giardiasis, solutionphase synthesis of a library of isoflavone derivatives has been accomplished. Of the products screened, several compounds such as P(A1,B1) and P(A1,B11) exhibited potent antigiardial activity. The details of synthesis, in vitro antigiardial assay, and preliminary structure-activity relationships of these compounds are described.
Combinatorial Chemistry & High Throughput Screening
Title: Solution-Phase Parallel Synthesis of an Isoflavone Library for the Discovery of Novel Antigiardial Agents
Volume: 5 Issue: 6
Author(s): T. Mineno, K.M. Stanford, L.A. Walker and M.A. Avery
Affiliation:
Abstract: Combinatorial chemistry has become a dramatically useful tool for the development of new medicinal agents. In the search to discover a novel and effective lead for the treatment of giardiasis, solutionphase synthesis of a library of isoflavone derivatives has been accomplished. Of the products screened, several compounds such as P(A1,B1) and P(A1,B11) exhibited potent antigiardial activity. The details of synthesis, in vitro antigiardial assay, and preliminary structure-activity relationships of these compounds are described.
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Cite this article as:
T. Mineno , K.M. Stanford , L.A. Walker and M.A. Avery , Solution-Phase Parallel Synthesis of an Isoflavone Library for the Discovery of Novel Antigiardial Agents, Combinatorial Chemistry & High Throughput Screening 2002; 5 (6) . https://dx.doi.org/10.2174/1386207023330138
DOI https://dx.doi.org/10.2174/1386207023330138 |
Print ISSN 1386-2073 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5402 |
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