Enhancement of Combinatorial Chemistry by Microwave-Assisted Organic Synthesis

Author(s): Pelle Lidstrom, Jacob Westman, Anthony Lewis

Journal Name: Combinatorial Chemistry & High Throughput Screening
Accelerated Technologies for Biotechnology, Bioassays, Medicinal Chemistry and Natural Products Research

Volume 5 , Issue 6 , 2002

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Abstract:

It was in the 1980s that the first papers in which the use of either combinatorial methods or microwave heating in organic chemistry were published. Unlike combinatorial chemistry, which quite readily became an accepted method, particularly in the pharmaceutical industry, it is only now that microwave heating is truly gaining acceptance. Our aim in this review is to attempt to rationalize this slow acceptance and to show the benefits to be gained by employing microwave heating in tandem with combinatorial chemistry. We will also give a number of examples of successful applications.

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Article Details

VOLUME: 5
ISSUE: 6
Year: 2002
Page: [441 - 458]
Pages: 18
DOI: 10.2174/1386207023330147
Price: $65

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