Molecular Recognition: Design of “Keys”

Author(s): Beining Chen, Sergey Piletsky, Anthony P.F. Turner

Journal Name: Combinatorial Chemistry & High Throughput Screening
Accelerated Technologies for Biotechnology, Bioassays, Medicinal Chemistry and Natural Products Research

Volume 5 , Issue 6 , 2002

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Abstract:

Molecular recognition between molecules is one of the most fundamental processes in biology and chemistry. The recognition process is largely driven by non-covalent forces such as hydrogen bonding, electrostatics, van der Waals forces, π-π interactions, and conformational energy. The complementarity between the receptor and substrate is very similar to the “lock and key” function, first described by Emil Fischer over 100 years ago, - the lock being the molecular receptor such as a protein or enzyme and the key being the substrate such as a drug, that is recognized to give a defined receptor-substrate complex. This review focuses on the design of specific ligand systems as “Keys” to enable the induced fit of these keys into the target macromolecules, protein/enzyme (Locks) with particular emphasis on protein recognition.

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Article Details

VOLUME: 5
ISSUE: 6
Year: 2002
Page: [409 - 427]
Pages: 19
DOI: 10.2174/1386207023330129
Price: $65

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