Cascade Synthesis with (Triphenylphosphoranylidene)-Ethenone as a Versatile Reagent for Fast Synthesis of Heterocycles and Unsaturated Amides under Microwave Dielectric Heating

Author(s): J. Westman, K. Orrling

Journal Name: Combinatorial Chemistry & High Throughput Screening
Accelerated Technologies for Biotechnology, Bioassays, Medicinal Chemistry and Natural Products Research

Volume 5 , Issue 7 , 2002

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A general procedure for the synthesis of a large variety of compounds comprising an α, β-unsaturated carbonyl functionality was developed. The use of one-pot cascade synthesis with (triphenylphosphoranylidene) ethenone as a versatile reagent for various formations including heterocycles of different ring sizes and unsaturated amides in combination with microwave dielectric heating is described. The method was used to synthesize a small library of unsaturated amides.

Keywords: Microwave heating, one-pot synthesis, cascade reaction, library synthesis, (triphenylphosphoranylidene)ethenone

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Article Details

Year: 2002
Page: [571 - 574]
Pages: 4
DOI: 10.2174/1386207023330066
Price: $65

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